Objective of this meeting
The goal of the meeting is to provide an overview of these three emerging fields with respect to CFLD:
the clinical course of CFLD into adulthood; the definition of relevant parameters for CFLD development and severity to assess the effects of novel treatments;
the understanding of CFLD development based on studies in novel experimental models
Three developments are expected to have major influences on the prevention and treatment of CFLD and on the understanding of its pathophysiology :
.Biomarkers and non invasive tools to measure liver fibrosis
Treatments including CFTR correctors or potentiators, and bile acid analogues or antifibrotic agents ;
Experimental models allowing for pathophysiologic and mechanistic studies and identify possible targets of interventions. Recently the possible roles of the intestinal microbiome, of nuclear hormone activation and of extra-epithelial expression of CFTR in the development of CFLD have been hypothesized .
This monothematic conference on CFLD is a unique chance to provide an overview of these emerging fields :
the clinical course of CFLD into adulthood ;
the definition of relevant parameters for CFLD development and severity to assess the effects of novel treatments ;
the understanding of CFLD development based on studies in novel experimental models.