اساتید - دانشکده پزشکی دانشگاه علوم پزشكي و خدمات بهداشتی درمانی تبريز

دانشکده پزشکی دانشگاه علوم پزشكي و خدمات بهداشتی درمانی تبريز - اکرم مهنا

اکرم مهنا

فیزیک پزشکی

درجه علمی : استادیار

تحصیلات : Ph.D

رشته تحصیلی : فیزیک پزشکی

محل تحصیل : دانشگاه تربیت مدرس تهران

تلفن : 33364660

توضیحات :

آدرس پست الکترونیکی : mahna@tbzmed.ac.ir

دانلود فایل CV

دانلود فایل

تماس با ما

درباره

سوابق تحصیلی

مقالات ارائه شده

مقالات چاپ شده در مجلات

عنوان مقاله : The Effect of Time-Varying Low Intensity ELF Magnetic Field on Growth Rate of Invasive Ductal Carcinoma on Balb/C Mice

نویسنده رابط :

عنوان مجله و شماره مجله : Zahedan Journal of Research in Medical Sciences ;14

نویسندگان : Akram Mahna, S. Mohammad Firoozabadi, Zeinab Shankayi

سال انتشار : 2012

چکیده : Background: Extremely low frequency ( ELF ) magnetic fields have been considered by researchers as a noninvasive treatment approach. Citing documented biological effects of ELF magnetic fields in recent studies, we investigate the effect of low intensity ELF magnetic field on the treatment of invasive ductal carcinoma tumor. Materials and Methods : Female Balb/c mice were transplanted with invasive ductal carcinoma tumors. Extremely low frequency magnetic field ( 100 pulse per second EMF ( 150 μT ) ) with static magnetic field ( 400 μT ) as a background exposure was applied as a combined protocol for the treatment of the tumors. Other treatment groups in this study were control group ( with no treatment ) , static magnetic field exposure group at 400 μT ( sham group ) , chemotherapy by bleomycin intratumoral injection group and finally a group with the combined protocol after intratumoral injection of bleomycin. All groups were treated in the magnetic field for 10 minutes per day for 12 days. Results: The results of this study showed that static and ELF magnetic field had no significant effect on the invasive ductal carcinoma tumor growth process. But static magnetic field indicated a significant decrease in tumor growth in the last days of the follow up. Also combined protocol significantly increased toxic effect of bleomycin as a chemotherapy agent. Conclusion: Low intensity static magnetic field can be considered as an antitumor factor. Also combined magnetic fields can be used for increasing the effects of chemotherapy in cancerous patients.

عنوان مقاله : Environmental 50Hz Magnetic Fields Can Increase Viability of Human Umbilical Vein Endothelial Cells (HUVEC)

نویسنده رابط :

عنوان مجله و شماره مجله : Iranian Journal of Medical Physics;13

نویسندگان : Akram Mahna Seyed Mohamad Firoozabadi

سال انتشار : 2016

چکیده : Introduction Over the last decades, considerable levels of electromagnetic fields (EMFs) have been characterized in the living environment. Recent epidemiological studies on occupational and residential exposure to EMF have shown that 50/60 Hz fields, known as extremely low frequencies (ELF), have various biological effects, such as angiogenesis. This study aimed to investigate the effect of environmental 50 Hz magnetic fields at intensities of 3, 6, 15, 46, 110 and 207 T on human umbilical vein endothelial cells (HUVECs) as a significant component of angiogenesis process. Materials and Methods In this study, 43 experimental groups were evaluated, including a control group, 6 sham exposure groups, 18 acute, and 18 chronic exposure groups with different exposure intensities and durations of exposure. Proliferation and viability of HUVECs were examined via cell counting and MTT methods, respectively. Results No significant changes were observed in the proliferation of HUVECs by 50 Hz magnetic field, while the viability of some acute groups was found to increase. These findings confirmed the theory of "biological window" for magnetic fields. Conclusion According to the results of this study, since the 50 Hz magnetic field can effect on viability of HUVECs and these cells play a key role in angiogenesis, 50 Hz magnetic fields at the mentioned intensities probably could be effective in the improvement of angiogenesis process.

دانلود

عنوان مقاله : The Effect of ELF Magnetic Field on Tumor Growth after Electrochemotherapy

نویسنده رابط :

عنوان مجله و شماره مجله : Journal of membrane biology

نویسندگان : A. Mahna S. M. P. Firoozabadi Z. Shankayi

سال انتشار : 2013

چکیده : From a fundamental point of view, chemotherapy is the most widely used treatment for cancers despite its side effects on normal cells and tissues. Electrochemotherapy (ECT) is a method for increasing the permeability of cancer cells to drugs and, hence, decreasing their dosage. It apparently creates electropores on the cell membrane using electric pulses. ECT can decrease tumor volume; but this effect is not permanent, and partial regrowth has been reported. The aim of this study was to investigate the potential of magnetic ﬁelds in preventing the regrowth of tumors after ECT. Tumoral Balb/c mice were exposed to a magnetic ﬁeld (15 mT, 50 Hz) for 12 days after treating additionally with 70 V/cm electric pulses and bleomycin at the ﬁrst day. The magnetic ﬁeld caused a signiﬁcant reduction in tumor volumes, while there was no signiﬁcant difference between the ECT and the electroporation with ECT and magnetic ﬁeld groups. The exploited magnetic ﬁeld (15 mT, 50 Hz) could decrease the tumor growth rate signiﬁcantly, without any effect on ECT efﬁciency.

دانلود

عنوان مقاله : The effects of pulsed magnetic field exposure on the permeability of leukemia cancer cells

نویسنده رابط :

عنوان مجله و شماره مجله : Electromagnetic biology and midicine

نویسندگان : Zeinab Shankayi S. Mohammad P. Firoozabadi Mahsa Mansourian Akram Mahna

سال انتشار : 2013

چکیده : Purpose: The newer methods of cancer treatment require new idea of drug delivery in cancer cells. Due to numerous researches electromagnetic field affect on cell function and cell membrane for possible therapeutic and drug delivery. In this article, we determined in vitro uptake of fluorescent dyes into the attached K562 cells due to time-varying magnetic field exposure. Method and material: The K562 cells were exposed to magnetic pulses via Magstim stimulator and double 70 mm coil. The strength and duration of pulses in all experiments were the same and three different frequencies of 0.25, 1 and 10 Hz pulses for 56, 112 and 28 numbers of pulses were applied (nine experimental groups) and uptake of Ly and PI was measured in each group. Result: Our results show that magnetic field can efficiently increase permeability. Among the treatment groups, the system gives the optimal permeabilization when cells are exposed to a train of 28 pulses with 1 Hz frequency.

دانلود

دانشکده پزشکی دانشگاه علوم پزشكي و خدمات بهداشتی درمانی تبريز - اکرم مهنا

اکرم مهنا

درباره

سوابق تحصیلی

مقالات ارائه شده

مقالات چاپ شده در مجلات

عنوان مقاله : The Effect of Time-Varying Low Intensity ELF Magnetic Field on Growth Rate of Invasive Ductal Carcinoma on Balb/C Mice

عنوان مقاله : Environmental 50Hz Magnetic Fields Can Increase Viability of Human Umbilical Vein Endothelial Cells (HUVEC)

عنوان مقاله : The Effect of ELF Magnetic Field on Tumor Growth after Electrochemotherapy

عنوان مقاله : The effects of pulsed magnetic field exposure on the permeability of leukemia cancer cells

تماس الکترونیکی